The estrogen connection to ADHD By Linda Roggli Before menopause, "Sylvia" was plagued by severe PMS (now known as PMDD - Pre Menstrual Dysphoric Disorder). She had migraines each month in tandem with her period and her work suffered because she lost focus regularly. After menopause her brain fog worsened. Little did she know that her undiagnosed ADHD was part of the hormonal snafu. Estrogen, specifically estradiol, the predominant estrogen for women during childbearing years, has come under scrutiny as a potent influence on cognition, memory and plasticity of the brain. Research released from the University of Massachusetts at Amherst and UCLA shows that estradiol can act like a neurotransmitter as well as a hormone in the bloodstream. The UMass/UCLA study revealed that estradiol is actually created within the neurons of the pre-frontal cortex and facilitates the speedy transmission of neurologic impulses. Estradiol also increases the concentration of
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